At Regulus, we have fostered a culture that values scientific rigor, creative problem solving, collaboration across departments and disciplines, and persistence in the face of obstacles.

Above all else, we are inspired by the many individuals worldwide affected by genetic kidney diseases and other genetically-based, orphan diseases.

Located in San Diego, California, we are a dedicated team of scientists, researchers, and biotech professionals committed to learning and growth, and to the patients we serve.

Current Openings.

Senior - Principal Scientist, Drug Metabolism and Pharmacokinetic (DMPK)

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Position Description and Scope:

We are currently seeking an experienced Senior Scientist of Drug Metabolism and Pharmacokinetics (DMPK) to join our team to advance our compounds through preclinical and clinical development. The successful candidate will be involved in drug discovery and development through the conduct of in vitro and in vivo drug metabolism studies designed to understand the uptake of oligonucleotides and/or oligonucleotide conjugates into plasma and tissues as well as their biotransformation pathways/routes of elimination. The successful candidate should have experience working on projects with oligonucleotides, peptides, or small molecules.


Job responsibilities:

  • Selecting, operating and maintaining mass spectrometric equipment for structure elucidation of metabolites/catabolites as well as chemical modifications/degradation products in complex biologic matrices.
  • Interpret mass spectral data to make structural assignments. Proficiency in WinNonLin Software is desired.
  • Perform quantitative analyses using HPLC/MS/MS and HPLC-Fluorescence.
  • Contribute to the preparation, editing, review of documents for regulatory submission (i.e., study reports, IB’s, IND’s).
  • Mentor scientists and research associates supporting preclinical and clinical PK activities

Position Requirements:

  • PhD in Pharmaceutical Sciences, Biochemistry, Chemistry, or related discipline, with 5 drug discovery experience. Biotech or pharm industry setting preferred.
  • BSc/MS in a related discipline, with 8 years of experience. Biotech or pharm industry setting preferred.
  • Strong fundamental understanding of various DMPK areas such as physicochemical properties, pharmacokinetic (PK), drug-metabolizing enzyme, as well as transporter kinetics.
  • Hands-on experience in method development, sample extraction from various tissues/plasma, and performing quantitative and qualitative analyses using HPLC/MS/MS and HPLC-Fluorescence are strongly desired.

Personal Competencies:

  • Ability to think critically, work independently and collaborate in a team environment
  • Collaborate in a team environment with both internal members of the group as well as discovery/development project teams
  • Effective interpersonal skills, including both written and oral communication skills
  • Highly organized, strong analytical skills, highly attentive to details
  • Strong work ethic, ability to work within schedules and deadline
  • Team player, intensely committed to success and getting the job done well in a highly dynamic environment
  • Ability to multitask, prioritize, and function in a fast-paced entrepreneurial environment


Regulus Therapeutics Inc. (Nasdaq: RGLS) is a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs. Regulus has leveraged its oligonucleotide drug discovery and development expertise to develop a well-balanced microRNA therapeutics pipeline complemented by a rich intellectual property estate to retain its leadership in the microRNA field.

Regulus is advancing several programs in renal, and central nervous systems diseases.

Regulus is located in San Diego, California, and is led by a seasoned executive team experienced in corporate management, business, science, drug discovery, and development. Regulus’ scientific advisory board consists of world-class scientists and some of the foremost authorities in the field of microRNA research. Excellent salary and benefits package offered.

For immediate consideration, please apply to

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Regulus Therapeutics, Inc, is proud to be an EEO Employer



Regulus provides a competitive benefits package that includes a choice of health, vision, and dental insurance, life insurance, flexible spending accounts, 401K plan, vacation and stock options.

We believe that you, as an employee, matter above everything else. We back that statement up continuously with a unique approach to providing you with great benefits and valuable resources. Our benefits packages and resources are designed to support you in creating the life and work style that brings your best to your community, your family and Regulus’ mission of addressing significant unmet medical needs.

Most of our benefits cover employees who work at least 30 hours a week and their eligible dependents. Eligible dependents include:

  • A spouse or domestic partner
  • Children (biological, step, foster, adopted or legal charge) up to age 26
  • The majority of our benefits become effective immediately on the date of hire without any pre-existing condition exclusion (temporary employees, contractors, interns and co-ops are not eligible for benefits).

In addition to an array of health and financial benefits and learning opportunities, we offer competitive compensation and bonus programs that reward you for your contributions toward achieving the company’s mission and strategic goals. We also provide you with a wide range of services designed to help make life easier while you are at work, so you can spend your free time doing more of the things you enjoy most.