JOIN OUR TEAM.

At Regulus, we have fostered a culture that values scientific rigor, creative problem solving, collaboration across departments and disciplines, and persistence in the face of obstacles.

Above all else, we are inspired by the many individuals worldwide affected by genetic kidney diseases and other genetically-based, orphan diseases.

Located in San Diego, California, we are a dedicated team of scientists, researchers, and biotech professionals committed to learning and growth, and to the patients we serve.

Current Openings.

Scientist – Translational Biology

Learn more

Position description and scope:

The successful candidate will be a hands-on cell and molecular biologist and will provide important skills and prior experience in translational research for the organization. Reporting to the Executive Director of Biology, the incumbent will be part of our translational biology team and conduct important research for our various programs. The incumbent will also have the opportunity to participate in various aspects of the drug discovery process: from target identification, lead characterization, through to IND-enabling activities. Candidates who possess strong scientific curiosity and have a proven track record of elucidating complex biological processes (including molecular and cellular) are encouraged to apply.

Job responsibilities

  • Independently design and perform in vitro and in vivo assays/studies to characterize the specific functions of molecular targets and elucidate the mechanism of action (MOA) of miR therapeutics in different disease areas.
  • Independently identify and assess the capabilities of external CRO(s) to aid our internal research efforts. Independently plan, coordinate and manage the execution of CRO studies.
  • Independently conduct experiments in support of our translational biology team aimed at discovering and developing novel biomarkers and assays, devising patient stratification strategies, elucidating MOAs and more.
  • Participate in various activities of the drug discovery process: from target identification/validation, lead identification/optimization, through to nomination of clinical candidate and assisting in IND-enabling activities.
  • Maintain a high level of familiarity and understanding of the current literature on RNA biology, novel oligotherapeutic technologies, and how they relate to specific therapeutic areas of interest – leveraging those knowledges to support existing programs and to explore/propose novel molecular targets opportunities.
  • Highly qualified candidate who desires the opportunity to grow as a drug discovery and translational research scientist in the field of RNA therapeutics is strongly encouraged to apply.

Position Requirements:

  • PhD in Cell and/or Molecular Biology or related discipline, with at least 3-5 years of post-doctoral drug discovery experience. Biotech or pharm industry setting preferred.
  • BSc/MS in related discipline, with at least 8-10 years of experience in a biotech or pharm industry setting, strong publication record and demonstrated success in oligotherapeutic research will also be considered.
  • Prior experience in the field of translational research and elucidating complex biological processes is a must.
  • Prior experience in RNA biology and nephrology is preferred.
  • Experience in working with and managing CROs and academic collaborations is desired.

Techniques desired:

  • Strong experience in various cell and molecular biology techniques including, cell culture (primary and stable cell lines), transfection, stable cell line generation, FACS analysis, MACS cell separation, Luciferase-reporter, MSD, ELISA, RNA purification, RT-qPCR, western blots and other standard cell-based or biochemical assays, are required.
  • Proficiency in basic computer data analysis and presentation applications: e.g. Microsoft Word, Excel, and PowerPoint

Personal Competencies:

  • Effective interpersonal skills, including both written and oral communication skills
  • Highly organized, strong analytical skills, highly attentive to details.
  • Strong work ethic, ability to work within schedules and deadline
  • Team player, intensely committed to success and getting the job done well in a highly dynamic environment
  • Ability to multitask, prioritize, and function in a fast-paced entrepreneurial environment
  • Self-motivated, ability to work independently while also willing to follow protocols
  • Willingness to rapidly learn new laboratory and data analysis methods
  • Demonstrated ability to generate reproducible results, and to teach others

For immediate consideration, please apply to careers@regulusrx.com

NO PHONE CALLS PLEASE.  PRINCIPALS ONLY

Regulus Therapeutics Inc. is proud to be an EEO Employer.

Scientist I – Neuroscience/Translational Biology

Learn more

Position description and scope:

This position is intended for a highly qualified candidate who desires the opportunity to grow as a drug discovery scientist and project team leader in the fields of microRNA/oligonucleotides and CNS-related therapeutics.  The successful candidate will be a hands-on cell and molecular biologist and will provide important research experience and skills for the organization. Reporting to the Senior Director of Biology, the incumbent will have the opportunity to lead-from-the-bench and participate in various aspects of the drug discovery process: from target identification/validation, lead identification/optimization, through to nomination of clinical candidates and assisting in IND-enabling activities. The individual will be primarily responsible for establishing in vitro phenotypic screens and driving hit-to-lead development from the bench.  Candidates who possess strong scientific curiosity and have a proven track record of elucidating complex biological processes are encouraged to apply.

Job responsibilities

  • Independently design, develop, validate and perform cell-based and cell-free assays to evaluate and screen the activities of potential microRNA therapeutics, and to elucidate  mechanisms of molecular targets.
  • Evaluate and establish new assays in support of phenotypic, CNS-related disease modeling processes; optimize screening assay endpoints and readouts in support of early target identification and validation efforts.
  • Maintain a high level of understanding for current literature on microRNA biology, disease areas of primary interest and oligotherapeutic technologies; leverage such knowledge to support existing programs and to propose novel opportunities.
  • Coordinate, manage and execute studies with external CRO(s) (in vivo and in vitro).

Position Requirements:

  • PhD in Cell and/or Molecular Biology or related discipline; postdoc experience preferred (2-3 years).  Candidates with postdoc training in a biotech/pharm industry setting are particularly encouraged to apply.
  • BSc/MS in a related discipline, with ~3-6 years of experience in a biotech or pharm industry setting.  Demonstrated success in oligotherapeutic research and/or experience in neuroscience desired, but greater preference for candidates with strong technical skills and knowledge in assay development, optimization and screening practices.
  • Hands-on experience with disease-based cell modeling is strongly desired (e.g., CNS inflammatory, seizure and neurodegenerative); experience with in vivo disease models and/or ex vivo manipulation of primary cell types or iPSC-derived is a plus.
  • Experience working with and managing CROs/academic collaborations is a plus.
  • Working understanding of the principles of pharmacokinetics and pharmacodynamics.

Techniques desired:

  • Expertise in cell and molecular biology techniques including advanced cell culture, transfection, luciferase-reporter, MSD, ELISA, RNA purification, RT-qPCR, Western blotting and other standard cell-based or biochemical assays are required.  Ability to independently troubleshoot, learn new assays and establish new platforms is essential.
  • Neuroscience, or disease area-focused background, with experience developing novel assay systems for molecular target characterization and modeling of complex disease processes, such as through application of primary neuronal/glial cultures, patient-derived cell lines, iPSC models and functional phenotyping.
  • Experience with tissue/cell-specific targeting for functional delivery of therapeutics is a plus (e.g., aptamer-based delivery, receptor/ligand conjugations).
  • Familiarity and interest in NGS analyses and functional genomic approaches is a plus.
  • Proficiency in basic computer data analysis and presentation applications: e.g., Microsoft Word, Excel, and PowerPoint.

Personal Competencies:

  • Highly effective interpersonal skills, including both written and oral communication skills
  • Highly organized, strong analytical skills and attentive to details
  • Strong work ethic, ability to work within schedules and deadline
  • Team player, intensely committed to success and getting the job done
  • Ability to multitask, prioritize, and function in a fast-paced entrepreneurial environment
  • Self-motivated, ability to work independently while also willing to follow protocols
  • Willingness to rapidly learn new laboratory and data analysis methods
  • Demonstrated ability to generate reproducible results, and to teach others

For immediate consideration, please apply to careers@regulusrx.com

NO PHONE CALLS PLEASE.  PRINCIPALS ONLY

Regulus Therapeutics Inc. is proud to be an EEO Employer.

Benefits.

Regulus provides a competitive benefits package that includes a choice of health, vision, and dental insurance, life insurance, flexible spending accounts, 401K plan, vacation and stock options.

We believe that you, as an employee, matter above everything else. We back that statement up continuously with a unique approach to providing you with great benefits and valuable resources. Our benefits packages and resources are designed to support you in creating the life and work style that brings your best to your community, your family and Regulus’ mission of addressing significant unmet medical needs.

Most of our benefits cover employees who work at least 30 hours a week and their eligible dependents. Eligible dependents include:

  • A spouse or domestic partner
  • Children (biological, step, foster, adopted or legal charge) up to age 26
  • The majority of our benefits become effective immediately on the date of hire without any pre-existing condition exclusion (temporary employees, contractors, interns and co-ops are not eligible for benefits).

In addition to an array of health and financial benefits and learning opportunities, we offer competitive compensation and bonus programs that reward you for your contributions toward achieving the company’s mission and strategic goals. We also provide you with a wide range of services designed to help make life easier while you are at work, so you can spend your free time doing more of the things you enjoy most.