Position description and scope:
The successful candidate will become an integral member of the Translational Medicine team and will provide important skills and experience in biology (both in vitro and in vivo) for advancing our programs.
Reporting to the Vice President of Translational Medicine, this individual will have the opportunity to participate in various aspects of the drug discovery and development process: from target identification/validation, lead identification/optimization, through to nomination of clinical candidates, assisting in IND-enabling activities, and supporting translational research activities.
Candidates who possess strong scientific curiosity, have a proven track record of elucidating complex biological processes, and are interested in participating in the discovery and development of RNA medicines are encouraged to apply. Strong background in RNA/microRNA biology is highly desirable. Basic understanding of oligonucleotides drug discovery and development is a plus.
Job responsibilities:
- Independently design and execute studies (including cell/molecular biology and pharmacology) to elucidate the mechanism of action (MOA) for RNA/microRNAs of interest. Working with a cross-functional team: discover, validate, and understand the relationships between molecular pathways and relevant biomarkers associated with MOA and drug response.
- Maintain a high level of familiarity and understanding of current RNA/microRNA literature and how they relate to specific therapeutic areas of interest. Leveraging that knowledge to support and expand existing programs and to explore new RNA/microRNA opportunities for unmet medical needs.
- Manage CROs and academic collaborations.
Techniques desired:
- Experience and proficiency with general cell and molecular biology techniques including basic cell culture, primary and 3D culture, cell transfection, proliferation and cytotoxicity assays, luciferase reporter assays, ELISA/MSD, Western blots, DNA/RNA purification, vector construction, library preparation, PCRs, and other standard cell-based or biochemical assay is required.
- Prior experience with in vivo biology, including animal husbandry and experimental designs, handling, drug dosing, tissue sampling, and study endpoints including immunohistochemistry.
- Proficiency in scientific experimental design, manuscript preparation, presentations, journal review and publication editing are a must.
- Prior experience in studies and basic bioinformatic (e.g., NGS) analysis is a plus.
- Accurate and robust data reporting is essential.
Position Requirements:
- Ph.D. in biologically relevant field (e.g., Cell and Molecular Biology, Pharmacology, Oncology and/or Nephrology) with at least 3-5 years of industry experience.
- Experience in working with and managing CROs and academic collaborations.
- A good understanding of basic pharmacokinetics and pharmacodynamics principles is desirable.
- Proficiency in basic computer data analysis and presentation applications: e.g., Microsoft Word, Excel, GraphPad, and PowerPoint is essential.
Personal Competencies:
- Team player, with effective interpersonal, written, and presentation skills.
- Self-motivated, ability to multitask, prioritize, and work independently.
- Highly organized, attentive to details, and strong analytical skills.
- Strong work ethic demonstrating the ability to generate reproducible results.
- Ability to follow existing protocols and eagerness to learn new laboratory techniques and data analysis methods.
The anticipated salary range for this role is $110,000- $145,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location, and relevant education or training.
In addition, this position offers an annual bonus and eligibility to participate in stock and ESPP plans. Benefits offered include a retirement savings plan (with company match), paid vacation, and health benefits to include medical, dental, and vision coverage in accordance with the terms and conditions of the applicable plans.
Regulus Therapeutics Inc. (Nasdaq: RGLS) is a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs. Regulus has leveraged its oligonucleotide drug discovery and development expertise to develop a well-balanced microRNA therapeutics pipeline complemented by a rich intellectual property estate to retain its leadership in the microRNA field. Regulus is advancing several programs in renal and central nervous systems diseases.
Regulus is in La Jolla, California and is led by a seasoned executive team experienced in corporate management, business, science, drug discovery and development. Regulus’ scientific advisory board consists of world-class scientists and some of the foremost authorities in the field of microRNA research.
For immediate consideration, please apply to careers@regulusrx.com
You can visit our website to find out more about our company and culture: www.RegulusRx.com.
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Regulus Therapeutics, Inc, is proud to be an EEO Employer.
