Overview
Anal Biochem, Anal Biochem. 2006 Dec 15;359(2):268-70. Epub 2006 Sep 8
Cell Metab, Esau et al. (2006) Cell Metab., 3, 87-98
Extension the results confirming the interesting therapeutic potential due to pharmacological intervention with miR-122 by another type microRNA inhibitors (ASOs) and a longer treatment protocol. After 4 weeks, ASO-122-treated mice exhibited decreased cholesterol and triglyceride levels without changes in plasma glucose concentrations. Isolated hepatocytes of treated mice exhibited decreased hepatic fatty-acid synthesis and sterol synthesis as well as increased fatty-acid oxidation. [more]
Nucleic Acid Res, Davis et al. (2006) Nucleic Acids Res., 34, 2294-304
This study defines important factors for designing improved microRNA targeting ASOs, enabling more effective microRNA functionalization and therapeutic targeting. [more]
