Overview
Nature, Nature. 2005 Feb 17;433(7027):769-73. Epub 2005 Jan 30
Nature, Krutzfeldt et al. (2005) Nature 438, 685-689
This study describes the exciting finding that cholesterol-modified RNA oligonucleotides, termed “antagomirs”, can be used to functionally inactivate microRNAs in various tissues in a mouse. Specifically, it was shown that an abundant liver-specific microRNA can be inactivated for a long time, resulting in changes in abundance of distinct mRNAs. This finding demonstrates that microRNAs can function as a sensor to fine-tune gene expression, and suggests that antagomirs can be applied as therapeutics for disease. [more]
